Plexin-B2 controls the timing of differentiation and the motility of cerebellar granule neurons

Plexin-B2 deletion leads to aberrant lamination of cerebellar granule neurons (CGNs) and Purkinje cells. Although in the cerebellum is only expressed by proliferating CGN precursors outer external layer (oEGL), its function development still elusive. Here, we used 3D imaging, vivo electroporation live-imaging techniques study novel cerebellum-specific Plxnb2 conditional knockout mice. We show that CGNs mutants not escape oEGL mix with newborn postmitotic CGNs. Furthermore, motility mitotic early altered. Together, this formation ectopic patches at surface an intermingling normally time-stamped parallel fibers molecular (ML), arborization cell dendrites. There results suggest restricts might have a cytokinesis.